Antipsychotic-induced weight gain: A review of the literature.

This article reviews what is currently known about antipsychotic-induced weight gain, describes the magnitude of the problem, briefly touches on mechanisms of action, and addresses the correlation.

Among conventional agents, mean weight change ranged from a reduction of 0.39 kg with molindone to an increase of 3.19 kg with thioridazine. Among newer antipsychotic agents, mean increases were as follows: clozapine, 4.45 kg; olanzapine, 4.15 kg; sertindole, 2.92 kg; risperidone, 2.10 kg; and ziprasidone, 0.04 kg.

Antipsychotic-Induced Weight Gain: A Comprehensive.

Weight gain associated with atypical antipsychotics is a common problem that requires effective management. The selection of an agent with a low risk of weight gain, such as risperidone or ziprasidone, is central to such management. Send article to Kindle.A comprehensive literature review of all available articles on the mechanisms and management of antipsychotic-induced weight gain was done by searching databases PsychINFO and PubMed. A summary of the available guidelines for monitoring of antipsychotic-induced weight gain and metabolic syndrome is also provided.A literature review was then compiled of evi-dence for the consensus points. This review and recommendations was circulated to the consensus group participants. Their feed-back was, as far as possible, incorporated into the final version of the guidelines. The guideline recommendations are linked to relevant evi-dence through the literature review.


Introduction: Antipsychotic-induced weight gain (WG) and metabolic abnormalities are major concerns. This review was untaken to answer if there is a weight-neutral second-generation antipsychotic for bipolar disorder (BPD).Background: Antipsychotic-induced weight gain (AIWG) and other adverse metabolic effects represent serious side effects faced by many patients with psychosis that can lead to numerous comorbidities and which reduce the lifespan.

In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain. 1.

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Metformin for atypical antipsychotic-induced weight gain and glucose metabolism dysregulation: review of the literature and clinical suggestions. CNS Drugs. 2010; 24(3):193-206 (ISSN: 1179-1934) Hasnain M; Vieweg WV; Fredrickson SK.

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The current evidence base for possible interventions regarding the management of antipsychotic-induced weight gain was also evaluated. Results and conclusion: On the basis of the literature review, there are several speculated reasons for the increase in prescriptions of second-generation antipsychotics.

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Several studies have investigated interventions for antipsychotic-induced, or less commonly mood stabilizer-induced, weight gain. Both lifestyle and pharmacological interventions have demonstrated effectiveness. We systematically review randomized controlled trials of pharmacological interventions for weight gain related to these medications.

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How to manage antipsychotic induced weight gain Non-pharmacological methods should always be considered first to manage antipsychotic induced weight gain2. Barriers to weight loss, such as poor diet and reduced physical exercise should be addressed in all cases, regardless of whether any further interventions are used.

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MINIMIZING ANTIPSYCHOTIC SIDE EFFECT 3 Abstract Adherence to antipsychotic medication has demonstrated significant impact in decreasing symptom exacerbation among patients diagnosed with mental illness.

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Get help with your assignments, homework, coursework, essays, dissertations and so much more from the best in tutoring and academic help. We provide affordable, high quality academic writing assistance to students at all leveals of study. Place your order for free.

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Allison DB, Mentore JL, Heo M, Chandler LP, Cappelleri JC, Infante MC et al. Antipsychotic-induced weight gain: A comprehensive research synthesis. American Journal of Psychiatry. 1999 Nov 1;156(11):1686-1696.

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CRD COMMENTARY: This review is based on an extensive search of the literature aimed at identifying both published and unpublished material. The risk of publi. Antipsychotic-induced weight gain: a comprehensive research synthesis.

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However, while there is good evidence about antipsychotic-induced weight gain,10 present literature reveals little empirical evidence to com- pare treatment strategies to manage weight gain associated to treatment with antidepressants, and there are no formal indications, only clinical experience.

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